Vicious LQT induced by a combination of factors different from hERG inhibition

• Main Authors: Xinping Xu (Author), Yue Yin (Author), Dayan Li (Author), Binwei Yao (Author), Li Zhao (Author), Haoyu Wang (Author), Hui Wang (Author), Ji Dong (Author), Jing Zhang (Author), Ruiyun Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinically, drug-induced torsades de pointes (TdP) are rare events, whereas the reduction of the human ether-à-go-go-related gene (hERG) current is common. In this study, we aimed to explore the specific factors that contribute to the deterioration of hERG inhibition into malignant ventricular arrhy...