Vicious LQT induced by a combination of factors different from hERG inhibition

• 主要な著者: Xinping Xu (著者), Yue Yin (著者), Dayan Li (著者), Binwei Yao (著者), Li Zhao (著者), Haoyu Wang (著者), Hui Wang (著者), Ji Dong (著者), Jing Zhang (著者), Ruiyun Peng (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Clinically, drug-induced torsades de pointes (TdP) are rare events, whereas the reduction of the human ether-à-go-go-related gene (hERG) current is common. In this study, we aimed to explore the specific factors that contribute to the deterioration of hERG inhibition into malignant ventricular arrhy...