Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice

• Main Authors: Yuta Hara (Author), Tatsuma Honzawa (Author), Moeka Kitagawa (Author), Ritsuki Sano (Author), Kazuhiko Matsuo (Author), Takashi Nakayama (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced depression mouse model, we demonstrated that CCR4 d...