A Comparative Pharmacology Study Between the Intracolonic and Oral Routes of 5-FU Administration in a Colon Cancer-Bearing Yoshida Sarcoma Rat Model

• 主要な著者: Takeshi Goto (著者), Naoko Tomizawa (著者), Eiji Kobayashi (著者), Akio Fujimura (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2004-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg). At doses of ≥20 mg/kg and ≥30 mg/kg, the 5-FU intracolonic and oral administrati...