Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS

• Main Authors: Nirav P. Patel (Author), Mallika Sanyal (Author), Naveen Sharma (Author), Dinesh S. Patel (Author), Pranav S. Shrivastav (Author), Bhavin N. Patel (Author)
• Format: Book
• Published: Elsevier, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A highly selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay has been described for the determination of asenapine (ASE) in presence of its inactive metabolites N-desmethyl asenapine (DMA) and asenapine-N-glucuronide (ASG). ASE, and ASE 13C-d3, used as internal st...