RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening.

• Hauptverfasser: Saša Stefanić (Verfasst von), Jan Dvořák (Verfasst von), Martin Horn (Verfasst von), Simon Braschi (Verfasst von), Daniel Sojka (Verfasst von), Debbie S Ruelas (Verfasst von), Brian Suzuki (Verfasst von), Kee-Chong Lim (Verfasst von), Stephanie D Hopkins (Verfasst von), James H McKerrow (Verfasst von), Conor R Caffrey (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

BACKGROUND: The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has emerged as a straightforward and important techni...