RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening.

• Main Authors: Saša Stefanić (Author), Jan Dvořák (Author), Martin Horn (Author), Simon Braschi (Author), Daniel Sojka (Author), Debbie S Ruelas (Author), Brian Suzuki (Author), Kee-Chong Lim (Author), Stephanie D Hopkins (Author), James H McKerrow (Author), Conor R Caffrey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has emerged as a straightforward and important techni...