Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

• Main Authors: Yan Chen (Author), Chen Chen (Author), Xiaojuan Zhang (Author), Chuanchuan He (Author), Pengxuan Zhao (Author), Minsi Li (Author), Ting Fan (Author), Ruicong Yan (Author), Yao Lu (Author), Robert J. Lee (Author), Muhammad Waseem Khan (Author), Muhammad Sarfraz (Author), Xiang Ma (Author), Tan Yang (Author), Guangya Xiang (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt-CUR@PSPPN) to facilitate...