The application of next-generation sequencing to validate D12S391 microvariation

• Main Authors: Qingxia Zhang (Author), Jinjie Liu (Author), He Ren (Author), Shuai Sun (Author), Yi Zhao (Author), Chong Chen (Author), Li Jia (Author), Yacheng Liu (Author), Jiangwei Yan (Author)
• Formato: Livro
• Publicado em: Wolters Kluwer Medknow Publications, 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: In a paternity case, the D12S391 locus was reported as a mismatch. To confirm the existence of mutations and mutations come from father or mother. Methods: STR and next-generation sequencing technology were used to validate the sequence. Results: NGS showed the loss of one adenine between...