Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish

• Glavni autori: Giancarlo eBruni (Autor), Parth eLakhani (Autor), David eKokel (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2014-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based research in central nervous system (CNS) pharmacology. Researchers are us...