Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish

• Auteurs principaux: Giancarlo eBruni (Auteur), Parth eLakhani (Auteur), David eKokel (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2014-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based research in central nervous system (CNS) pharmacology. Researchers are us...