PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
Objective: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1. PGC-1α expression in the liver is highly elevated in obese and diabetic conditions, leading to increased hepatic glucose production. We previously s...
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Elsevier,
2018-01-01T00:00:00Z.
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