PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism

• Hauptverfasser: Jaemin Lee (Verfasst von), Mario Andrés Salazar Hernández (Verfasst von), Thomas Auen (Verfasst von), Patrick Mucka (Verfasst von), Justin Lee (Verfasst von), Umut Ozcan (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2018-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Objective: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1. PGC-1α expression in the liver is highly elevated in obese and diabetic conditions, leading to increased hepatic glucose production. We previously s...