PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism

• Main Authors: Jaemin Lee (Author), Mario Andrés Salazar Hernández (Author), Thomas Auen (Author), Patrick Mucka (Author), Justin Lee (Author), Umut Ozcan (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1. PGC-1α expression in the liver is highly elevated in obese and diabetic conditions, leading to increased hepatic glucose production. We previously s...