Inhibition of BMP4 and Alpha Smooth Muscle Actin Expression in LX-2 Hepatic Stellate Cells by BMP4-siRNA Lipid Based Nanoparticle

• Главные авторы: Refaat Omar (Автор), Jiaqi Yang (Автор), Samaa Alrushaid (Автор), Frank J. Burczynski (Автор), Gerald Y. Minuk (Автор), Yuewen Gong (Автор)
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• Опубликовано: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Предметы: article
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Purpose: To develop and characterize vitamin A (VA)-coupled liposomes for the targeted delivery of BMP4-siRNA to hepatic stellate cells (HSC). VA was selected to increase the uptake by HSC based on their function in the storage of VA. Methods: DOTAP/DOPE liposomes were prepared by film hydration met...