Inhibition of BMP4 and Alpha Smooth Muscle Actin Expression in LX-2 Hepatic Stellate Cells by BMP4-siRNA Lipid Based Nanoparticle

Purpose: To develop and characterize vitamin A (VA)-coupled liposomes for the targeted delivery of BMP4-siRNA to hepatic stellate cells (HSC). VA was selected to increase the uptake by HSC based on their function in the storage of VA. Methods: DOTAP/DOPE liposomes were prepared by film hydration met...

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Bibliographic Details
Main Authors: Refaat Omar (Author), Jiaqi Yang (Author), Samaa Alrushaid (Author), Frank J. Burczynski (Author), Gerald Y. Minuk (Author), Yuewen Gong (Author)
Format: Book
Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
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3rd Floor Main Library

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