Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production

• Auteurs principaux: Neta Gotlieb (Auteur), Irena Tachlytski (Auteur), Yelena Lapidot (Auteur), Maya Sultan (Auteur), Michal Safran (Auteur), Ziv Ben-Ari (Auteur)
• Format: Livre
• Publié: BMC, 2018-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Background Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum levels of vitamin D are associated with increased hepatitis B virus (HBV)...