Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

Patients with chronic kidney disease (CKD) suffer from arterial media calcification and a disturbed bone metabolism. Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the calcification inhibitor pyrophosphate (PPi) into inorganic phosphate (Pi) and thereby stimulates arterial media calcifica...

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Main Authors: Britt Opdebeeck (Author), Ellen Neven (Author), José Luis Millán (Author), Anthony B. Pinkerton (Author), Patrick C. D'Haese (Author), Anja Verhulst (Author)
Format: Book
Published: MDPI AG, 2021-07-01T00:00:00Z.
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3rd Floor Main Library

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