Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

• 主要な著者: Britt Opdebeeck (著者), Ellen Neven (著者), José Luis Millán (著者), Anthony B. Pinkerton (著者), Patrick C. D'Haese (著者), Anja Verhulst (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Patients with chronic kidney disease (CKD) suffer from arterial media calcification and a disturbed bone metabolism. Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the calcification inhibitor pyrophosphate (PPi) into inorganic phosphate (Pi) and thereby stimulates arterial media calcifica...