In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging

• Main Authors: Zhonghua Wang (Author), Bingshu He (Author), Yaqi Liu (Author), Meiling Huo (Author), Wenqing Fu (Author), Chunyan Yang (Author), Jinfeng Wei (Author), Zeper Abliz (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) was established for direct analysis of metabolites i...