A novel somatic BRCA2 point mutation in a metastatic pancreatic cancer patient: a case report

• Main Authors: Deqiang Wang (Author), Ruting Guan (Author), Qing Tao (Author), Sisi Liu (Author), Man Yu (Author), Xiaoqin Li (Author)
• Format: Bog
• Udgivet: BMC, 2021-01-01T00:00:00Z.
• Fag: article
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Abstract Background In addition to ovarian and breast cancers, loss-of-function mutations in BRCA1 and BRCA2 genes are also linked to an increased risk of pancreatic cancer, with ~ 4 to 7% of pancreatic cancer patients harboring germline BRCA mutations. Most BRCA alterations in pancreatic cancer are...