A novel somatic BRCA2 point mutation in a metastatic pancreatic cancer patient: a case report

• मुख्य लेखकों: Deqiang Wang (लेखक), Ruting Guan (लेखक), Qing Tao (लेखक), Sisi Liu (लेखक), Man Yu (लेखक), Xiaoqin Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2021-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background In addition to ovarian and breast cancers, loss-of-function mutations in BRCA1 and BRCA2 genes are also linked to an increased risk of pancreatic cancer, with ~ 4 to 7% of pancreatic cancer patients harboring germline BRCA mutations. Most BRCA alterations in pancreatic cancer are...