A novel somatic BRCA2 point mutation in a metastatic pancreatic cancer patient: a case report

• Asıl Yazarlar: Deqiang Wang (Yazar), Ruting Guan (Yazar), Qing Tao (Yazar), Sisi Liu (Yazar), Man Yu (Yazar), Xiaoqin Li (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: BMC, 2021-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Background In addition to ovarian and breast cancers, loss-of-function mutations in BRCA1 and BRCA2 genes are also linked to an increased risk of pancreatic cancer, with ~ 4 to 7% of pancreatic cancer patients harboring germline BRCA mutations. Most BRCA alterations in pancreatic cancer are...