Synthesized natural peptides from amphibian skin secretions increase the efficacy of a therapeutic vaccine by recruiting more T cells to the tumour site

• Main Authors: Xuan Pan (Author), Bowei Ma (Author), Xinchao You (Author), Shu Chen (Author), Jialing Wu (Author), Tianfang Wang (Author), Shelley F. Walton (Author), Jianwei Yuan (Author), Xiaolian Wu (Author), Guoqiang Chen (Author), Yuejian Wang (Author), Guoying Ni (Author), Xiaosong Liu (Author)
• Format: Book
• Published: BMC, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Therapeutic vaccines against cervical cancer remain ineffective. Previously, we demonstrated that blocking the signalling of a cytokine, interleukin 10, at the time of immunisation elicited significantly higher numbers of antigen specific T cells and inhibited tumour growth in mi...