Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase
Simultaneous inhibition of multiple kinases has been suggested to provide synergistic effects on inhibition of tumour growth and resistance. This study describes the design, synthesis and evaluation of 18 compounds incorporating a pyrrolo[2,3-d]pyrimidine scaffold for dual inhibition of epidermal gr...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Taylor & Francis Group,
2018-01-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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