Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors

• Những tác giả chính: Shengqiang Shen (Tác giả), Wei Chen (Tác giả), Lili Dong (Tác giả), Qing Yang (Tác giả), Huizhe Lu (Tác giả), Jianjun Zhang (Tác giả)
• Định dạng: Sách
• Được phát hành: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

GH20 human β-N-acetylhexosaminidases (hsHex) and GH84 human O-GlcNAcase (hOGA) are involved in numerous pathological processes and emerged as promising targets for drug discovery. Based on the catalytic mechanism and structure of the catalytic domains of these β-N-acetylhexosaminidases, a series of...