Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes

• Główni autorzy: Katelyn A. Bustin (Autor), Arwa Abbas (Autor), Xie Wang (Autor), Michael C. Abt (Autor), Joseph P. Zackular (Autor), Megan L. Matthews (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity. Clostridioides difficile is a major nosocomial pat...