Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes

• Main Authors: Katelyn A. Bustin (Author), Arwa Abbas (Author), Xie Wang (Author), Michael C. Abt (Author), Joseph P. Zackular (Author), Megan L. Matthews (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity. Clostridioides difficile is a major nosocomial pat...