SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma

• Main Authors: Hye Seung Lee (Author), Wonkyung Jung (Author), Eunjung Lee (Author), Hyeyoon Chang (Author), Jin Hyuk Choi (Author), Han Gyeom Kim (Author), Aeree Kim (Author), Baek-hui Kim (Author)
• Format: Book
• Published: Korean Society of Pathologists & the Korean Society for Cytopathology, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor. Overexpression of SIRT7 and deacetylation of H3K18ac have been shown to be associated with a...