SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma

• Glavni autori: Hye Seung Lee (Autor), Wonkyung Jung (Autor), Eunjung Lee (Autor), Hyeyoon Chang (Autor), Jin Hyuk Choi (Autor), Han Gyeom Kim (Autor), Aeree Kim (Autor), Baek-hui Kim (Autor)
• Format: Knjiga
• Izdano: Korean Society of Pathologists & the Korean Society for Cytopathology, 2016-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Background SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor. Overexpression of SIRT7 and deacetylation of H3K18ac have been shown to be associated with a...