Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase

• Asıl Yazarlar: Yu Zhou (Yazar), Jun Liu (Yazar), Mingyue Zheng (Yazar), Shuli Zheng (Yazar), Chunyi Jiang (Yazar), Xiaomei Zhou (Yazar), Dong Zhang (Yazar), Jihui Zhao (Yazar), Deju Ye (Yazar), Mingfang Zheng (Yazar), Hualiang Jiang (Yazar), Dongxiang Liu (Yazar), Jian Cheng (Yazar), Hong Liu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2016-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Human 5-lipoxygenase (5-LOX) is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders. Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds, 3a and 3b, exhibiting a poten...