Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase

• Main Authors: Yu Zhou (Author), Jun Liu (Author), Mingyue Zheng (Author), Shuli Zheng (Author), Chunyi Jiang (Author), Xiaomei Zhou (Author), Dong Zhang (Author), Jihui Zhao (Author), Deju Ye (Author), Mingfang Zheng (Author), Hualiang Jiang (Author), Dongxiang Liu (Author), Jian Cheng (Author), Hong Liu (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human 5-lipoxygenase (5-LOX) is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders. Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds, 3a and 3b, exhibiting a poten...