Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients

• Hauptverfasser: Malgorzata Labuda (Verfasst von), Sophie Laberge (Verfasst von), Julie Brière (Verfasst von), Denis Bérubé (Verfasst von), Patrick Beaulieu (Verfasst von), Tomi Pastinen (Verfasst von), Maja Krajinovic (Verfasst von)
• Format: Buch
• Veröffentlicht: Hindawi Limited, 2011-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. The aim of this study was to test whether genetic variants in PDE4D gene, a key regulator of b2-adrenoceptor-induced cAMP turnover in airway smooth muscle cells, affect the response to sh...