Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.

• Auteurs principaux: Elizabeth A Misch (Auteur), Murdo Macdonald (Auteur), Chaman Ranjit (Auteur), Bishwa R Sapkota (Auteur), Richard D Wells (Auteur), M Ruby Siddiqui (Auteur), Gilla Kaplan (Auteur), Thomas R Hawn (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2008-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Toll-like receptors (TLRs) are important regulators of the innate immune response to pathogens, including Mycobacterium leprae, which is recognized by TLR1/2 heterodimers. We previously identified a transmembrane domain polymorphism, TLR1_T1805G, that encodes an isoleucine to serine substitution and...