Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.

• Main Authors: Elizabeth A Misch (Author), Murdo Macdonald (Author), Chaman Ranjit (Author), Bishwa R Sapkota (Author), Richard D Wells (Author), M Ruby Siddiqui (Author), Gilla Kaplan (Author), Thomas R Hawn (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toll-like receptors (TLRs) are important regulators of the innate immune response to pathogens, including Mycobacterium leprae, which is recognized by TLR1/2 heterodimers. We previously identified a transmembrane domain polymorphism, TLR1_T1805G, that encodes an isoleucine to serine substitution and...