Evidence for NADPH oxidase activation by GPR40 in pancreatic β-cells

• Hauptverfasser: Gabriela Nunes Marsiglio-Librais (Verfasst von), Eloisa Aparecida Vilas-Boas (Verfasst von), Christopher Carlein (Verfasst von), Markus Daniel Alexander Hoffmann (Verfasst von), Leticia Prates Roma (Verfasst von), Angelo Rafael Carpinelli (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Objective: Investigate the involvement of the fatty acids receptor GPR40 in the assembly and activation of NADPH oxidase and the implications on pancreatic β-cell function. Methods: BRIN-BD11 β-cells were exposed to GPR40 agonist (GW9508) or linoleic acid in different glucose concentrations. Superox...