Evidence for NADPH oxidase activation by GPR40 in pancreatic β-cells

• Main Authors: Gabriela Nunes Marsiglio-Librais (Author), Eloisa Aparecida Vilas-Boas (Author), Christopher Carlein (Author), Markus Daniel Alexander Hoffmann (Author), Leticia Prates Roma (Author), Angelo Rafael Carpinelli (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Investigate the involvement of the fatty acids receptor GPR40 in the assembly and activation of NADPH oxidase and the implications on pancreatic β-cell function. Methods: BRIN-BD11 β-cells were exposed to GPR40 agonist (GW9508) or linoleic acid in different glucose concentrations. Superox...