Novel glucokinase activators: A structure-based pharmacophore modeling, QSAR analysis, and molecular dynamics approach

• Κύριοι συγγραφείς: Mansour Al-Sayed Ahmad (Συγγραφέας), Belal O. Al-Najjar (Συγγραφέας), Ashok Shakya (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Pensoft Publishers, 2024-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Glucokinase (GK) activators are promising candidates for type 2 diabetes treatment. This study utilized structure-based pharmacophore modeling and QSAR analysis to identify novel activators. Virtual screening of a 250,000-compound library yielded eight new candidates with significant in vitro activi...