Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin

• Main Authors: Muhammad Umair Naseem (Author), Gabor Tajti (Author), Attila Gaspar (Author), Tibor G. Szanto (Author), Jesús Borrego (Author), Gyorgy Panyi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It inhibits Kv1.1-Kv1.3 ion channels in picomolar concentrations. This toxin is widely used to study physiological function of Kv ion channels in various cell types, including immune cells. Isolation of native MgT...