Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin

• Prif Awduron: Muhammad Umair Naseem (Awdur), Gabor Tajti (Awdur), Attila Gaspar (Awdur), Tibor G. Szanto (Awdur), Jesús Borrego (Awdur), Gyorgy Panyi (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It inhibits Kv1.1-Kv1.3 ion channels in picomolar concentrations. This toxin is widely used to study physiological function of Kv ion channels in various cell types, including immune cells. Isolation of native MgT...