Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin

• Główni autorzy: Muhammad Umair Naseem (Autor), Gabor Tajti (Autor), Attila Gaspar (Autor), Tibor G. Szanto (Autor), Jesús Borrego (Autor), Gyorgy Panyi (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It inhibits Kv1.1-Kv1.3 ion channels in picomolar concentrations. This toxin is widely used to study physiological function of Kv ion channels in various cell types, including immune cells. Isolation of native MgT...