How to Achieve Sufficient Endogenous Insulin Suppression in Euglycemic Clamps Assessing the Pharmacokinetics and Pharmacodynamics of Long-Acting Insulin Preparations Employing Healthy Volunteers

The therapeutic effect of basal insulin analogs will be sustained at a rather low insulin level. When employing healthy volunteers to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of long-acting insulin preparations by euglycemic clamp techniques, endogenous insulin cannot be ignored an...

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Main Authors: Hui Liu (Author), Ting Li (Author), Hongling Yu (Author), Jiaqi Li (Author), Huiwen Tan (Author), Yerong Yu (Author)
Format: Book
Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
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