The Guanylyl Cyclase Activator YC-1 Directly Inhibits the Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells

• Egile Nagusiak: Won Sun Park (Egilea), Jae-Hong Ko (Egilea), Eun A Ko (Egilea), Youn Kyoung Son (Egilea), Da Hye Hong (Egilea), In Duk Jung (Egilea), Yeong-Min Park (Egilea), Tae-Hoon Choi (Egilea), Nari Kim (Egilea), Jin Han (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2010-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We investigated the effects of YC-1, an activator of soluble guanylyl cyclase (sGC), on voltage-dependent K+ (Kv) channels in smooth muscle cells from freshly isolated rabbit coronary arteries by using the whole-cell patch clamp technique. YC-1 inhibited the Kv current in a dose-dependent fashion wi...