The Guanylyl Cyclase Activator YC-1 Directly Inhibits the Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells

• Main Authors: Won Sun Park (Author), Jae-Hong Ko (Author), Eun A Ko (Author), Youn Kyoung Son (Author), Da Hye Hong (Author), In Duk Jung (Author), Yeong-Min Park (Author), Tae-Hoon Choi (Author), Nari Kim (Author), Jin Han (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of YC-1, an activator of soluble guanylyl cyclase (sGC), on voltage-dependent K+ (Kv) channels in smooth muscle cells from freshly isolated rabbit coronary arteries by using the whole-cell patch clamp technique. YC-1 inhibited the Kv current in a dose-dependent fashion wi...