USP10 Targeted Self-Deliverable siRNA to Prevent Scarring in the Cornea

• Autores principales: Edward F. Boumil (Autor), Nileyma Castro (Autor), Andrew T. Phillips (Autor), Jon E. Chatterton (Autor), Sean M. McCauley (Autor), Alexey D. Wolfson (Autor), Taisia Shmushkovich (Autor), Marc Ridilla (Autor), Audrey M. Bernstein (Autor)
• Formato: Libro
• Publicado: Elsevier, 2020-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Ocular scarring after surgery, trauma, or infection leads to vision loss. The transparent cornea is an excellent model system to test anti-scarring therapies. Cholesterol-conjugated fully modified asymmetric small interfering RNAs (siRNAs) (self-deliverable siRNAs [sdRNAs]) are a novel modality for...