Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?

• Main Authors: Víctor Collado-Díaz (Author), Maria Ángeles Martinez-Cuesta (Author), Maria Amparo Blanch-Ruiz (Author), Ainhoa Sánchez-López (Author), Patricia García-Martínez (Author), José E Peris (Author), Iris Usach (Author), Maria Dolores Ivorra (Author), Alessandra Lacetera (Author), Sonsoles Martín-Santamaría (Author), Juan V. Esplugues (Author), Angeles Alvarez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the interplay between Abacavir and P2X7R in generating vas...