Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?

• Asıl Yazarlar: Víctor Collado-Díaz (Yazar), Maria Ángeles Martinez-Cuesta (Yazar), Maria Amparo Blanch-Ruiz (Yazar), Ainhoa Sánchez-López (Yazar), Patricia García-Martínez (Yazar), José E Peris (Yazar), Iris Usach (Yazar), Maria Dolores Ivorra (Yazar), Alessandra Lacetera (Yazar), Sonsoles Martín-Santamaría (Yazar), Juan V. Esplugues (Yazar), Angeles Alvarez (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the interplay between Abacavir and P2X7R in generating vas...