Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?

• Glavni autori: Víctor Collado-Díaz (Autor), Maria Ángeles Martinez-Cuesta (Autor), Maria Amparo Blanch-Ruiz (Autor), Ainhoa Sánchez-López (Autor), Patricia García-Martínez (Autor), José E Peris (Autor), Iris Usach (Autor), Maria Dolores Ivorra (Autor), Alessandra Lacetera (Autor), Sonsoles Martín-Santamaría (Autor), Juan V. Esplugues (Autor), Angeles Alvarez (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the interplay between Abacavir and P2X7R in generating vas...