In Vitro Hb Production in Β-thalassemia Patients Is Not a Predictor of Clinical Responsiveness to Hydroxyurea

• Hauptverfasser: Mohammad Reza MAHDAVI (Verfasst von), Farzin POURFARZAD (Verfasst von), Mehrnoush KOSARYAN (Verfasst von), Mohammad Taghi AKBARI (Verfasst von)
• Format: Buch
• Veröffentlicht: Tehran University of Medical Sciences, 2017-06-01T00:00:00Z.
• Schlagworte: article
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Background: The hematologic response to hydroxyurea (HU) is varied among β-thalassemia (BT) patients. The BCL11A and SOX6 genes are involved in response to HU. This study aimed to investigate the in-vitro responsiveness of HU among BT major patients homozygote for IVSII-1G>A mutation and XmnI sin...