One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

• मुख्य लेखकों: Sadahiro Naka (लेखक), Tadashi Watabe (लेखक), Thomas Lindner (लेखक), Jens Cardinale (लेखक), Kenta Kurimoto (लेखक), Melissa Moore (लेखक), Mitsuaki Tatsumi (लेखक), Yuriko Mori (लेखक), Eku Shimosegawa (लेखक), Frank Valla (लेखक), Hiroki Kato (लेखक), Frederik L. Giesel (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: SpringerOpen, 2021-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high accumulation within human tumors in clinical studies. However, [18F]Al...