mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia

• Main Authors: Lauren M. Paolella (Author), Sarmistha Mukherjee (Author), Cassie M. Tran (Author), Bruna Bellaver (Author), Mindy Hugo (Author), Timothy S. Luongo (Author), Swapnil V. Shewale (Author), Wenyun Lu (Author), Karthikeyani Chellappa (Author), Joseph A. Baur (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multiple roles have been described for mTOR complex 1 (...