mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia

• मुख्य लेखकों: Lauren M. Paolella (लेखक), Sarmistha Mukherjee (लेखक), Cassie M. Tran (लेखक), Bruna Bellaver (लेखक), Mindy Hugo (लेखक), Timothy S. Luongo (लेखक), Swapnil V. Shewale (लेखक), Wenyun Lu (लेखक), Karthikeyani Chellappa (लेखक), Joseph A. Baur (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multiple roles have been described for mTOR complex 1 (...