mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia

• Автори: Lauren M. Paolella (Автор), Sarmistha Mukherjee (Автор), Cassie M. Tran (Автор), Bruna Bellaver (Автор), Mindy Hugo (Автор), Timothy S. Luongo (Автор), Swapnil V. Shewale (Автор), Wenyun Lu (Автор), Karthikeyani Chellappa (Автор), Joseph A. Baur (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2020-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objective: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multiple roles have been described for mTOR complex 1 (...