Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

• मुख्य लेखकों: Danqi Chen (लेखक), Aijun Shen (लेखक), Guanghua Fang (लेखक), Hongchun Liu (लेखक), Minmin Zhang (लेखक), Shuai Tang (लेखक), Bing Xiong (लेखक), Lanping Ma (लेखक), Meiyu Geng (लेखक), Jingkang Shen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2016-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Histone acetylation is a critical process in the regulation of chromatin structure and gene expression. Histone deacetylases (HDACs) remove the acetyl group, leading to chromatin condensation and transcriptional repression. HDAC inhibitors are considered a new class of anticancer agents and have bee...