Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

• 主要な著者: Danqi Chen (著者), Aijun Shen (著者), Guanghua Fang (著者), Hongchun Liu (著者), Minmin Zhang (著者), Shuai Tang (著者), Bing Xiong (著者), Lanping Ma (著者), Meiyu Geng (著者), Jingkang Shen (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2016-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Histone acetylation is a critical process in the regulation of chromatin structure and gene expression. Histone deacetylases (HDACs) remove the acetyl group, leading to chromatin condensation and transcriptional repression. HDAC inhibitors are considered a new class of anticancer agents and have bee...