Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

• Main Authors: Danqi Chen (Author), Aijun Shen (Author), Guanghua Fang (Author), Hongchun Liu (Author), Minmin Zhang (Author), Shuai Tang (Author), Bing Xiong (Author), Lanping Ma (Author), Meiyu Geng (Author), Jingkang Shen (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone acetylation is a critical process in the regulation of chromatin structure and gene expression. Histone deacetylases (HDACs) remove the acetyl group, leading to chromatin condensation and transcriptional repression. HDAC inhibitors are considered a new class of anticancer agents and have bee...